You’ve probably heard the buzz about NAD—but what is it really, and why is it suddenly everywhere in the wellness and beauty world? Short for nicotinamide adenine dinucleotide, NAD is a coenzyme found in every cell of the body. It plays a major role in cellular energy, DNA repair, metabolic health, and even reducing inflammation—aka all the stuff that supports healthy aging.
With NAD levels declining as we age, more people are turning to NAD supplementation—especially NAD injections—as a safe, natural way to boost metabolism, support brain health, and promote anti-aging from the inside out.
Wondering if it’s worth adding to your wellness routine? In this article, we’ll explore:
- What NAD therapy does for the body
- Whether NAD therapy really works
- The potential benefits and side effects
- Why it’s become a go-to therapy for anti-aging
Let’s explore how NAD therapy works and how our knowledgeable and professional staff at Aesthetics MedSpa in Reno, NV, can help you make the most of this treatment.
What Does NAD Therapy Do for the Body?
NAD, or nicotinamide adenine dinucleotide, is a powerhouse coenzyme found in every single cell of your body. It plays a key role in hundreds of metabolic and cellular processes, especially those tied to energy production, DNA repair, and inflammation control—all major contributors to how we age and how good we feel doing it.
As we age, our blood NAD levels decline—in fact, research shows a 50% drop by middle age. This decline impacts the cellular repair systems that keep us feeling energized and youthful.
Here’s why NAD is an effective therapy for anti-aging:
- Boosts energy by supporting mitochondria—the engines of your cells
- Promotes DNA repair and helps reduce oxidative stress and inflammation
- Supports brain health and cognitive clarity by activating sirtuins, a family of proteins linked to longevity
- Improves skin health and cellular regeneration—hello, glow!
- Regulates metabolism and promotes healthy fat and sugar processing
Researchers like Dr. Shin-ichiro Imai and Dr. Eric Verdin, leaders at Washington University and the Buck Institute for Research on Aging, have explored the roles of NAD in the aging process and its potential to reverse age-related dysfunction.
NAD is naturally produced in the body, but it can also be boosted through NAD supplementation like nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN)—often taken as a dietary supplement or delivered more directly via injections or an IV drip.
Want to increase NAD levels and support healthy aging? Keep reading—we’re just getting to the good part.

Does NAD Really Work? Let’s Break It Down
Scientists have identified NAD decline as one of the hallmarks of aging, with levels dropping significantly in middle-aged and older adults. Since NAD is a key coenzyme involved in DNA repair, cellular energy, and metabolism, this decline is linked to fatigue, brain fog, and other age-related concerns.
But studies show that boosting NAD may reverse some of these effects.
What the science says:
- A clinical trial published in NPJ Aging found that oral NAD supplements were well-tolerated and significantly increased NAD+ levels in older adults.
- A study in Cell Reports showed that NR raised NAD levels in aged human skeletal muscle and improved markers of metabolism and sirt1 activity.
- Research from the Buck Institute for Research on Aging found that restoring NAD helped reverse dysfunction by reversing tissue NAD decline, with potential benefits for brain aging and fatty liver disease.
Real-life benefits clients report:
- More sustained energy and focus throughout the day
- Improved mental clarity and reduced “brain fog”
- Brighter, more radiant skin
- Better digestion and metabolic balance
- Less fatigue and quicker post-exercise recovery
While more research is needed to fully understand long-term effects, the science behind NAD is strong—and the real-world results are making believers out of skeptics.
NAD Therapy Benefits and Side Effects: What You Should Know
Now that we know how NAD works in the body, let’s talk about what you’ll actually feel when you start NAD therapy. Whether you’re struggling with low energy, brain fog, or just want to support your body’s natural aging process, this therapy offers real, noticeable benefits—often after just a few sessions.
Unlike oral supplements, NAD injections and IV drips allow your body to absorb it faster and in higher amounts. This makes it a great option if you’re looking for quicker results, especially for things like energy levels, metabolism, and skin clarity.
Here’s what people are loving about NAD therapy…
Some of the standout benefits of NAD therapy include:
- Increased energy and reduced fatigue
- Sharper mental clarity and improved mood
- Boosted metabolism and better support for weight balance
- Healthier skin and improved cellular repair
- Support for anti-aging, detox, and long-term wellness
- Enhanced roles in cellular processes, including DNA damage repair and treatment of metabolic dysfunction
Whether through nicotinamide riboside shots or IV drips, NAD can help restore age-related NAD decline and promote healthy aging.
Additional Reading: You should also learn Why Dermaplaning Facials Are Your New Skincare Must-Try.
Possible Side Effects of NAD IV Therapy and Shots
Like any dietary supplement or treatment, NAD therapy isn’t for everyone. While generally well-tolerated in clinical studies, mild side effects can occur.
Potential side effects may include:
- Headache
- Nausea or stomach upset
- Muscle cramping during infusion
People with certain health conditions or sensitivities should consult their provider first. The dosage matters—and that’s where expert, personalized care comes in.
During a session, expect a relaxed setting and customized support based on your body’s needs. It’s a calm, rejuvenating experience that often leaves people feeling recharged for days.
Is NAD Good for You? Exploring the Long-Term Impact
By now, you might be wondering—is NAD actually good for you in the long run? The answer from researchers and wellness experts is a growing yes.
NAD doesn’t just help you feel more energized today—it also plays a key role in how well your body ages over time. Because it supports DNA repair, cellular health, and brain function, many professionals consider NAD therapy a smart, proactive approach to healthy aging.
Some studies even suggest that raising NAD levels could slow down age-related decline, especially in areas like cognitive performance and metabolic health.
Here’s why NAD is being embraced as a long-term wellness tool:
- Helps protect brain cells and support mental clarity
- Aids in DNA repair and healthy cellular function
- Supports consistent energy levels and metabolism
- Contributes to overall longevity and resilience
As researchers continue to explore the full long-term effects of NAD therapy, it’s already becoming a favorite among those looking to stay sharp, strong, and vibrant as the years go by.

Is NAD Safe? What Experts and Research Say
When it comes to adding something new to your wellness routine, safety always comes first—and that includes NAD injections. So, is NAD safe? According to current research, the answer is yes—when administered properly and under the care of qualified professionals.
Studies have shown that NAD supplementation, including IV NAD and nicotinamide riboside (NR), is generally well-tolerated and does not produce serious adverse effects when used as directed (Nature Communications). However, the type of IV, dosage, and your individual health history matter—this is where expert care makes all the difference.
Here’s what to know about NAD safety:
- NAD is considered a dietary supplement and not FDA-approved as a drug
- Clinics like Aesthetics MedSpa follow strict safety protocols to ensure a clean, medical-grade environment
- NAD IV drip sessions are monitored for comfort, with personalized plans based on your body’s needs
- Mild side effects (headache, nausea, cramping) are rare and typically temporary
Choosing a trusted provider ensures your experience is not only effective—but safe, relaxing, and completely tailored toyou.
Additional Reading: Looking for more ways to stay healthy and energized? Take a look at the Top 6 Benefits of Vitamin Injections.
Glow From the Inside Out—Start NAD Therapy With Us
If you’re curious about NAD and how it might support your energy, skin, and overall vitality, Aesthetics MedSpa in Reno, NV, offers a personalized, luxurious way to get started.
Our NAD injections and IV drips are delivered by experienced medical professionals in a serene, spa-like environment. Every shot or IV drip is tailored to your individual needs—whether you’re looking to boost energy, support your metabolism, or simply feel more like yourself again. It’s wellness that feels as good as it works.
Want to learn more? Schedule a consultation to see if it’s right for you.
Ready to see what NAD therapy can do for your body and your glow? We can’t wait to help you feel your absolute best.